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Katacalcin acetate(85916-47-8 free base)

Catalog No. TP1062L CAS TP1062L

Synonyms: PDN 21 acetate

Katacalcin acetate(85916-47-8 free base) (PDN 21 acetate) is a potent plasma calcium-lowering peptide.

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Katacalcin acetate(85916-47-8 free base) Chemical Structure

Katacalcin acetate(85916-47-8 free base), CAS TP1062L

Pack Size	Availability	Price/USD
1 mg	In stock	$ 245.00
5 mg	In stock	$ 612.00
10 mg	In stock	$ 869.00
25 mg	In stock	$ 1,320.00
50 mg	In stock	$ 1,780.00
100 mg	In stock	$ 2,380.00

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Purity: 97.68%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Katacalcin acetate(85916-47-8 free base) (PDN 21 acetate) is a potent plasma calcium-lowering peptide.

In vitro

Katacalcin is a potent plasma calcium lowering peptide. Katacalcin belongs to the calcitonin family, that causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of these ions in the bones[1]. Katacalcin (KC) belongs to a small family of polypeptides that are encoded by the calc-1 gene and also include calcitonin (CT) and procalcitonin NH2-terminal cleavage peptide (N-ProCT). Katacalcin pretreatment leads to a concentration-dependent decrease at concentrations between 1 amol/liter and 10 fmol/liter and is a more potent inhibitor of fMLP-induced chemotaxis than CT or procalcitonin (PCT). Katacalcin deactivates CD14+ peripheral blood mononuclear cell (PBMC) chemotaxis not only toward N-formyl-Met-Leu-Phe (fMLP) but also toward other attractants of the chemokine family (heterologous deactivation) as well as toward PCT and CT. Pretreatment of CD14+ PBMCs with Katacalcin also deactivates subsequent chemotaxis toward Katacalcin itself. Katacalcin elicites concentration-dependent migration of CD14+ PBMC at concentrations from the atomolar to the micromolar range and deactivates attractant-induced chemotaxis. Katacalcin regulates human CD14+ PBMC migration via signaling events involving protein kinase A-dependent cAMP pathways[2].

Synonyms	PDN 21 acetate
Molecular Weight	2496.65
Formula	C99H158N34O38S2
CAS No.	TP1062L

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mM

References and Literature

1. Hillyard CJ, et al. Katacalcin: a new plasma calcium-lowering hormone. Lancet. 1983 Apr 16;1(8329):846-8.

Related compound libraries

This product is contained In the following compound libraries：

Peptide Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Keywords

Katacalcin acetate(85916-47-8 free base) TP1062L Others PDN 21 Acetate PDN-21 Acetate Katacalcin acetate(85916478 free base) PDN21 Acetate PDN 21 acetate Katacalcin acetate(85916 47 8 free base) inhibitor inhibit

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